GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11976180 | 1 | rs6464573 | chr7:143748098 | OR2A1 | chr7:144015236-144016148:+;chr7 | 0.19 | 4.18 | 3.41E-5 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs6464573 | chr7:143748098 | OR2A9P | chr7:143991573-143997832:+;chr7 | 0.3 | 6.62 | 9.84E-11 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs6464574 | chr7:143748257 | ARHGEF35 | chr7:143883677-143892736:- | -0.51 | -10.2 | 3.04E-22 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs6464574 | chr7:143748257 | OR2A1 | chr7:144015236-144016148:+;chr7 | -0.17 | -3.55 | 0.00042 | Obesity-related traits |
| THCA | cis | rs11976180 | 1 | rs6464574 | chr7:143748257 | OR2A9P | chr7:143991573-143997832:+;chr7 | -0.28 | -5.94 | 5.55E-9 | Obesity-related traits |
| THCA | cis | rs2157926 | 1 | rs6465117 | chr7:87293493 | DBF4 | chr7:87505544-87538856:+ | -0.28 | -3.82 | 0.000149 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs2157926 | 1 | rs6465118 | chr7:87330423 | DBF4 | chr7:87505544-87538856:+ | -0.27 | -3.71 | 0.000233 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs6465657 | 1 | rs6465657 | chr7:97816327 | BRI3 | chr7:97910979-97922275:+ | -0.11 | -4.02 | 6.89E-5 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6465657 | chr7:97816327 | TECPR1 | chr7:97846060-97881468:- | -0.13 | -3.72 | 0.000225 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6465658 | chr7:97816638 | BRI3 | chr7:97910979-97922275:+ | -0.1 | -3.76 | 0.000192 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs6465657 | 1 | rs6465658 | chr7:97816638 | TECPR1 | chr7:97846060-97881468:- | -0.13 | -3.52 | 0.00047 | Prostate cancer (gene x gene interaction);Prostate cancer |
| THCA | cis | rs41997 | 1 | rs6466656 | chr7:118042177 | ANKRD7 | chr7:117864712-117882782:+ | -0.28 | -4.56 | 6.55E-6 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs7528419 | 1 | rs646776 | chr1:109818530 | SYPL2 | chr1:110009100-110024763:+ | 0.15 | 3.41 | 0.000697 | Cholesterol, total;Myocardial infarction;Coronary artery disease;Lipoprotein-associated phospholipase A2 activity and mass |
| THCA | cis | rs12681963 | 1 | rs6468131 | chr8:29981020 | LEPROTL1 | chr8:29952922-29995222:+ | -0.19 | -4.19 | 3.38E-5 | Migraine |
| THCA | cis | rs12681963 | 1 | rs6468131 | chr8:29981020 | MBOAT4 | chr8:29989188-30002200:- | -0.34 | -4.55 | 6.95E-6 | Migraine |